Article
Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011
Scholer-Dahirel Alix, Schlabach Michael R, Loo Alice, Bagdasarian Linda, Meyer Ronald, Guo Ribo, Woolfenden Steve, Yu Kristine K, Markovits Judit, Killary Karen, Sonkin Dmitry, Yao Yung-Mae, Warmuth Markus, Sellers William R, Schlegel Robert, Stegmeier Frank, Mosher Rebecca E, McLaughlin Margaret E
Abstract excerpt
Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically validated by anticancer therapies that specifically inhibit oncoproteins such as BCR-ABL, c-Kit, HER2, PDGFR, and EGFR. Identifying additional genes that are required for tumor maintenance may lead to new targets for anticancer drugs. Although the role of...
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