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Article

Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.

Molecular and cellular biology - 1 Mar 2006

Zhang Wen, Chen Xi, Kato Yoichi, Evans Paul M, Yuan Subo, Yang Jun, Rychahou Piotr G, Yang Vincent W, He Xi, Evers B Mark, Liu Chunming

Abstract excerpt

Epithelial cells of the intestinal mucosa undergo a continual process of proliferation, differentiation, and apoptosis which is regulated by multiple signaling pathways. The Wnt/beta-catenin pathway plays a critical role in this process. Mutations in the Wnt pathway, however, are associated with...

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Identifiers

PMID: 16507986
DOI: 10.1128/MCB.26.6.2055-2064.2006
PMCID: PMC1430292

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16507986-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.PMID 16507986Read ↗

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The potential of targeting Wnt/β-catenin in colon cancerSemantic proximity Read ↗

Krüppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine.Semantic proximity Read ↗

Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cellsSemantic proximity Read ↗

TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.Semantic proximity Read ↗

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.Semantic proximity Read ↗

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal TumorigenesisSemantic proximity Read ↗

UXT-V1 contributes to the malignant phenotypes of colorectal cancer via GSK3β by activating Wnt/β-catenin pathwaySemantic proximity Read ↗

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.Semantic proximity Read ↗

Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.Semantic proximity Read ↗

Smad4 and p53 synergize in suppressing autochthonous intestinal cancerSemantic proximity Read ↗

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