Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Bryce Steven D, Morrison Vivienne, Craig Nicola J, Forsyth Nicholas R, Fitzsimmons Sara A, Ireland Hazel, Cuthbert Andrew P, Newbold Robert F, Parkinson E Kenneth

Abstract excerpt

Human chromosome 4 was previously shown to elicit features of senescence when introduced into cell lines that map to complementation group B for senescence, including HeLa cells. Subsequently, a DNA segment encoding the pseudogene Mortality Factor 4 (MORF4) was shown to reproduce some of the effects of the intact chromosome 4 and was suggested to be a candidate mortality gene. We have identified multiple MORF4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Chromosome Painting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Clone Cells

Share to Genes, Tumor Suppressor

Share to Genetic Complementation Test

Share to HeLa Cells

Share to Loss of Heterozygosity

Source

Open in PubMed Open full text

Identifiers

PMID: 12407449
DOI: 10.1038/sj.neo.7900268
PMCID: PMC1503669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.PMID 12407449Read ↗

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.Semantic proximity Read ↗

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene.Semantic proximity Read ↗

Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.Semantic proximity Read ↗

Molecular genetic approaches to the study of cellular senescence.Semantic proximity Read ↗

Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes.Semantic proximity Read ↗

Oligonucleotide microarray expression analysis of genes whose expression is correlated with tumorigenic and non-tumorigenic phenotype of HeLa x human fibroblast hybrid cells.Semantic proximity Read ↗

Suppression of X-ray-induced chromatid breaks in human tumor cells by introduction of normal chromosome 4.Semantic proximity Read ↗

Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression.Semantic proximity Read ↗

A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.Semantic proximity Read ↗

Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q.Semantic proximity Read ↗

The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.Semantic proximity Read ↗

Restoration of fragile histidine triad ( <i>FHIT</i> ) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.