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Suppression of X-ray-induced chromatid breaks in human tumor cells by introduction of normal chromosome 4.

Cancer genetics and cytogenetics - 1 Apr 2000

Parshad R, Ning Y, Sanford K K

Abstract excerpt

Human tumor cells in culture frequently show an infinite lifespan and are characterized by an abnormally high frequency of chromatid breaks after x-irradiation during G(2) phase of the cell cycle. This abnormally high frequency of persistent chromatid breaks results from deficient repair of the radiation-induced DNA damage. In three of four tumor cell lines, addition of a single human chromosome 4 from normal...

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PMID: 10731596
DOI: 10.1016/s0165-4608(99)00177-6

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