Article
Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes.
PloS one - 1 Jan 2011
Nawata Hisakatsu, Kashino Genro, Tano Keizo, Daino Kazuhiro, Shimada Yoshiya, Kugoh Hiroyuki, Oshimura Mitsuo, Watanabe Masami
Abstract excerpt
A change in chromosome number, known as aneuploidy, is a common characteristic of cancer. Aneuploidy disrupts gene expression in human cancer cells and immortalized human epithelial cells, but not in normal human cells. However, the relationship between aneuploidy and cancer remains unclear. To study the effects of aneuploidy in normal human cells, we generated artificial cells of human primary fibroblast having...
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