Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene.

Cancer research - 1 May 1999

Bryce S D, Forsyth N R, Fitzsimmons S A, Clark L J, Bertram M J, Cuthbert A P, Newbold R F, Pereira-Smith O M, Parkinson E K

Abstract excerpt

Approximately 50% of immortal human keratinocyte lines show loss of heterozygosity of chromosome region 4q33-q34, and the reintroduction of chromosome 4 into one such line, BICR 6, causes proliferation arrest and features of replicative senescence. Recently, a candidate gene, mortality factor 4 (MORF4), was identified in this region and sequenced in 21 immortal keratinocyte lines. There were no mutations or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 4

Share to Fibroblasts

Share to Keratinocytes

Share to Loss of Heterozygosity

Share to Skin Neoplasms

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10232582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene.PMID 10232582Read ↗

Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.Semantic proximity Read ↗

A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.Semantic proximity Read ↗

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.Semantic proximity Read ↗

Epithelial Cells Derived from Human Embryonic Stem Cells Display P16INK4A Senescence, Hypermotility, and Differentiation Properties Shared by Many P63+ Somatic Cell TypesSemantic proximity Read ↗

Molecular genetic approaches to the study of cellular senescence.Semantic proximity Read ↗

A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.Semantic proximity Read ↗

Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.Semantic proximity Read ↗

Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes.Semantic proximity Read ↗

Extended lifespan and immortalization of human fibroblasts induced by X-ray irradiation.Semantic proximity Read ↗

KRT14 haploinsufficiency results in increased susceptibility of keratinocytes to TNF-alpha-induced apoptosis and causes Naegeli-Franceschetti-Jadassohn syndrome.Semantic proximity Read ↗

The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.Semantic proximity Read ↗

A new case of keratin 14 functional knockout causes severe recessive EBS and questions the haploinsufficiency model of Naegeli-Franceschetti-Jadassohn syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.