Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.

Oncogene - 1 Aug 2002

Forsyth Nicholas R, Morrison Vivienne, Craig Nicola J, Fitzsimmons Sara A, Barr Nighean I, Ireland Hazel, Gordon Katrina E, Dowen Sally, Cuthbert Andrew P, Newbold Robert F, Bryce Steven D, Parkinson E Kenneth

Abstract excerpt

Squamous cell carcinoma (SCC) immortality is associated with p53 and INK4A dysfunction, high levels of telomerase and loss of heterozygosity (LOH) of other chromosomes, including chromosome 4. To test for a functional cancer mortality gene on human chromosome 4 we introduced a complete or fragmented copy of the chromosome into SCC lines by microcell-mediated chromosome transfer (MMCT). Human chromosome 4 caused a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Painting

Share to Chromosomes, Human, Pair 4

Share to In Situ Nick-End Labeling

Share to Loss of Heterozygosity

Share to Telomerase

Share to Telomere

Source

Identifiers

PMID: 12140764
DOI: 10.1038/sj.onc.1205688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.PMID 12140764Read ↗

A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.Semantic proximity Read ↗

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene.Semantic proximity Read ↗

Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma.Semantic proximity Read ↗

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.Semantic proximity Read ↗

Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.Semantic proximity Read ↗

The distal region of the long arm of human chromosome 1 carries tumor suppressor activity for a human fibrosarcoma line.Semantic proximity Read ↗

A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.Semantic proximity Read ↗

Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.Semantic proximity Read ↗

Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cells.Semantic proximity Read ↗

Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.