Article
Dobzhansky-Muller incompatibilities in protein evolution.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002
Kondrashov Alexey S, Sunyaev Shamil, Kondrashov Fyodor A
Abstract excerpt
We study fitness landscape in the space of protein sequences by relating sets of human pathogenic missense mutations in 32 proteins to amino acid substitutions that occurred in the course of evolution of these proteins. On average, approximately 10% of deviations of a nonhuman protein from its human ortholog are compensated pathogenic deviations (CPDs), i.e., are caused by an amino acid substitution that, at this...
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