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Article

Why human disease-associated residues appear as the wild-type in other species: genome-scale structural evidence for the compensation hypothesis.

Molecular biology and evolution - 1 Jul 2014

Xu Jinrui, Zhang Jianzhi

Abstract excerpt

Many human-disease associated amino acid residues (DARs) appear as the wild-type in other species. This phenomenon is commonly explained by the presence of compensatory residues in these other species that alleviate the deleterious effects of the DARs. The general validity of this hypothesis, however, is unclear, because few compensatory residues have been identified. Here we test the compensation hypothesis by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24723421
DOI: 10.1093/molbev/msu130
PMCID: PMC4069617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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