Article

Pairs of mutually compensatory frameshifting mutations contribute to protein evolution in vertebrates and insects

2020-12-26

Abstract excerpt

Insertions and deletions of lengths not divisible by 3 in protein-coding sequences cause frameshifts that usually induce premature stop codons and may carry a high fitness cost. However, this cost can be partially offset by a second compensatory indel restoring the reading frame. The role of such pairs of compensatory frameshifting mutations (pCFMs) in evolution has not been studied systematically. Here, we use wh...

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Literature Corpus work: 052b7158-d1a4-5001-b4d7-b04b0fa2f27d
DOI: 10.1101/2020.12.25.424394

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