Article
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes.
The Biochemical journal - 1 Feb 2013
Studer Romain A, Dessailly Benoit H, Orengo Christine A
Abstract excerpt
The present review focuses on the evolution of proteins and the impact of amino acid mutations on function from a structural perspective. Proteins evolve under the law of natural selection and undergo alternating periods of conservative evolution and of relatively rapid change. The likelihood of mutations being fixed in the genome depends on various factors, such as the fitness of the phenotype or the position of...
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