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Article

The Structural Determinants of Intra-Protein Compensatory Substitutions.

Molecular biology and evolution - 11 Apr 2022

Chaurasia Shilpi, Dutheil Julien Y

Abstract excerpt

Compensatory substitutions happen when one mutation is advantageously selected because it restores the loss of fitness induced by a previous deleterious mutation. How frequent such mutations occur in evolution and what is the structural and functional context permitting their emergence remain open questions. We built an atlas of intra-protein compensatory substitutions using a phylogenetic approach and a dataset...

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Identifiers

PMID: 35349721
DOI: 10.1093/molbev/msac063
PMCID: PMC9004419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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