Article
Determining the factors driving selective effects of new nonsynonymous mutations.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2017
Huber Christian D, Kim Bernard Y, Marsden Clare D, Lohmueller Kirk E
Abstract excerpt
The distribution of fitness effects (DFE) of new mutations plays a fundamental role in evolutionary genetics. However, the extent to which the DFE differs across species has yet to be systematically investigated. Furthermore, the biological mechanisms determining the DFE in natural populations remain unclear. Here, we show that theoretical models emphasizing different biological factors at determining the DFE,...
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