Article
Genetic constraints on protein evolution.
Critical reviews in biochemistry and molecular biology - 1 Jan 2000
Camps Manel, Herman Asael, Loh Ern, Loeb Lawrence A
Abstract excerpt
Evolution requires the generation and optimization of new traits ("adaptation") and involves the selection of mutations that improve cellular function. These mutations were assumed to arise by selection of neutral mutations present at all times in the population. Here we review recent evidence that indicates that deleterious mutations are more frequent in the population than previously recognized and that these...
Topics
- Animals
- Epistasis, Genetic
- Evolution, Molecular
- Humans
- Models, Biological
- Mutation
- Phylogeny
- Protein Conformation
- Proteins
- Thermodynamics