Article
Megakaryocyte polyploidization is associated with a functional gene amplification.
Blood - 15 Jan 2003
Raslova Hana, Roy Lydia, Vourc'h Claire, Le Couedic Jean Pierre, Brison Olivier, Metivier Didier, Feunteun Jean, Kroemer Guido, Debili Najet, Vainchenker William
Abstract excerpt
It is believed that polyploidy induces an orchestrated increase in gene expression. To know whether all alleles remain functional during megakaryocyte polyploidization, we used a well-established fluorescence in situ hybridization technique which allows one to simultaneously detect pre-mRNAs and assess ploidy level in a single cell. All alleles of GPIIb, GPIIIa, VWF, beta-actin, hsp70, c-mpl, Fli-1, and FOG-1...
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