Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Megakaryocyte polyploidization: role in platelet production

22 Sept 2019

Abstract excerpt

Mammal megakaryocytes (MK) undergo polyploidization during their differentiation. This process leads to a marked increase in the MK size and of their cytoplasm. Contrary to division by classical mitosis, ploidization allows an economical manner to produce platelets as they arise from the fragmentation of the MK cytoplasm. The platelet production in vivo correlates to the entire MK cytoplasm mass that depends both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31544577
DOI: 10.1080/09537104.2019.1667497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Megakaryocyte polyploidization: role in platelet productionPMID 31544577Read ↗

Roads to polyploidy: The megakaryocyte exampleSemantic proximity Read ↗

Normal and malignant megakaryopoiesisSemantic proximity Read ↗

Transcriptional characterization of human megakaryocyte polyploidization and lineage commitmentSemantic proximity Read ↗

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approachSemantic proximity Read ↗

Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytesSemantic proximity Read ↗

Fetal vs adult megakaryopoiesisSemantic proximity Read ↗

Megakaryopoiesis and Platelet Biology: Roles of Transcription Factors and Emerging Clinical Implications.Semantic proximity Read ↗

Megakaryocyte ontogeny: Clinical and molecular significance.Semantic proximity Read ↗

Endomitosis of Human Megakaryocytes Are Due to Abortive MitosisSemantic proximity Read ↗

Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies: the stochastic model revisited.Semantic proximity Read ↗

Molecular mechanisms of megakaryopoiesisSemantic proximity Read ↗

Cell cycle–dependent centrosome clustering precedes proplatelet formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.