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Transcriptional characterization of human megakaryocyte polyploidization and lineage commitment

18 Feb 2021

Abstract excerpt

BACKGROUND: Megakaryocytes (MKs) originate from cells immuno-phenotypically indistinguishable from hematopoietic stem cells (HSCs), bypassing intermediate progenitors. They mature within the adult bone marrow and release platelets into the circulation. Until now, there have been no transcriptional studies of primary human bone marrow MKs. OBJECTIVES: To characterize MKs and HSCs from human bone marrow using...

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PMID: 33587817
DOI: 10.1111/jth.15271

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