The relationship between human megakaryocyte nuclear DNA content and gene expression

Abstract excerpt

Increased platelet reactivity has been implicated in various vascular diseases. Since the protein content of platelets is determined mainly by the megakaryocyte, alterations in megakaryocyte mRNA expression may influence platelet protein content and therefore activity. In order to determine whether DNA content (ploidy) of a megakaryocyte influences its mRNA expression, we have developed a method to investigate...

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