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Fetal vs adult megakaryopoiesis

2 Feb 2022

Abstract excerpt

Fetal and neonatal megakaryocyte progenitors are hyperproliferative compared with adult progenitors and generate a large number of small, low-ploidy megakaryocytes. Historically, these developmental differences have been interpreted as "immaturity." However, more recent studies have demonstrated that the small, low-ploidy fetal and neonatal megakaryocytes have all the characteristics of adult polyploid...

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PMID: 35108353
DOI: 10.1182/blood.2020009301

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