Article
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression].
Molekuliarnaia biologiia - 1 Jan 2000
Timofeeva O A, Gorshkova E V, Levashova Z B, Kobzev V F, Filipenko M L, Kaledin V I, Merkulova T I
Abstract excerpt
The sequence of K-ras intron 2, which has been associated with lung tumor susceptibility in inbred mouse strains, was analyzed in susceptible strain GR and in resistant strains PT and UT. In the latter case, the intron had a tandem repeat of a 37-bp sequence with variant GC of its two single-nucleotide polymorphisms (SNPs), as earlier reported for resistant strains AKR, C57BL/c, and C3H/A. Strain GR did not...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- DNA-Binding Proteins
- GATA6 Transcription Factor
- Gene Expression Regulation
- Genes, ras
- Genetic Predisposition to Disease
- Introns
- Lung
- Lung Neoplasms
- Mice
- Mice, Inbred Strains