Article
The Ret proto-oncogene in the WAG/Rij rat strain: an animal model for inherited C-cell carcinoma?
Laboratory animals - 1 Jul 2003
De Miguel M, Fernández-Santos J M, Trigo-Sánchez I, Matera I, Ceccherini I, Martín I, Romeo G, Galera-Davidson H
Abstract excerpt
WAG/Rij rat strain has been suggested as an animal model for the study of inherited human medullary thyroid carcinoma (MTC), due to its high incidence of spontaneous C-cell thyroid tumours. Although the role of the Ret proto-oncogene mutations, as responsible for human MTC, is well established, nothing has been published concerning this putative animal model. Based upon the previously reported rat Ret sequence,...
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