Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lung cancer-associated SNP at the beginning of mouse k-ras gene intron 2 is essential for transcription factor binding.

Bulletin of experimental biology and medicine - 1 Jun 2006

Gorshkova E V, Kaledin V I, Kobzev V F, Merkulova T I

Abstract excerpt

The C to T substitution in position 311 n. p. of K-ras gene intron 2 in mice resistant to lung cancer (M. spretus) attenuates NF-Y transcription factor binding site in comparison with sensitive ICR mice (M. musculus). Appreciable differences between ICR and M. spretus in general pattern of binding of nuclear proteins to K-ras gene DNA within 248-332 n. p. fragment are demonstrated.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Binding Factor
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Introns

Share to Lung Neoplasms

Share to Mice, Inbred ICR

Share to Nuclear Proteins

Share to Oligonucleotides

Source

Identifiers

PMID: 17364062
DOI: 10.1007/s10517-006-0265-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Lung cancer-associated SNP at the beginning of mouse k-ras gene intron 2 is essential for transcription factor binding.PMID 17364062Read ↗

Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene.Semantic proximity Read ↗

Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility.Semantic proximity Read ↗

[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression].Semantic proximity Read ↗

Characterization of two protein-binding sites in the second intron of the mouse K-ras gene.Semantic proximity Read ↗

The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.Semantic proximity Read ↗

Pathogenesis of lung cancer signalling pathways: roadmap for therapies.Semantic proximity Read ↗

RAS and BRAF in the foreground for non-small cell lung cancer and colorectal cancer: Similarities and main differences for prognosis and therapies.Semantic proximity Read ↗

A mouse model to study inducible oncogene cooperation in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.