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Article

Effects of p21 on adult hippocampal neuronal development after irradiation

18 Jul 2018

Abstract excerpt

Abstract Inhibition of hippocampal neurogenesis is implicated in neurocognitive impairment after cranial irradiation. We recently demonstrated that disruption of neuronal development after DNA damage was regulated by p53. The cyclin-dependent kinase inhibitor 1 or p21, a downstream effector p53, mediates cell cycle arrest in response to DNA damage. There is evidence that p21 negatively regulates proliferation of...

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PMID: 30210818
DOI: 10.1038/s41420-018-0081-2

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