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Article

Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Pilaz Louis-Jan, Patti Dorothée, Marcy Guillaume, Ollier Edouard, Pfister Sabina, Douglas Rodney J, Betizeau Marion, Gautier Elodie, Cortay Veronique, Doerflinger Nathalie, Kennedy Henry, Dehay Colette

Abstract excerpt

The link between cortical precursors G1 duration (TG1) and their mode of division remains a major unresolved issue of potential importance for regulating corticogenesis. Here, we induced a 25% reduction in TG1 in mouse cortical precursors via forced expression of cyclin D1 and cyclin E1. We found...

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Identifiers

PMID: 19959663
DOI: 10.1073/pnas.0909894106
PMCID: PMC2788480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19959663-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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