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Article

The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2002

Hatta Toshihisa, Moriyama Kenji, Nakashima Kinichi, Taga Tetsuya, Otani Hiroki

Abstract excerpt

The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral...

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PMID: 12097503
PMCID: PMC6758239

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LIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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