Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia.

Leukemia & lymphoma - 1 Jul 2002

Schaich Markus, Illmer Thomas

Abstract excerpt

Resistance to cytotoxic therapy and development of refractory disease in acute myeloid leukemia (AML) is frequently associated with the expression of mdr1/P-gp. In the last years many potential signaling pathways leading to modulation of mdr1 expression have been described. Thus, it has been assumed that activated Ras may influence mdr1 expression. This activation can be realized by mutations in the Ras oncogene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, ras

Share to Leukemia, Myeloid

Share to Mutation

Share to Signal Transduction

Source

Identifiers

PMID: 12389613
DOI: 10.1080/10428190290033279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia.PMID 12389613Read ↗

Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia.Semantic proximity Read ↗

Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts.Semantic proximity Read ↗

Multidrug resistance in acute myeloid leukaemia.Semantic proximity Read ↗

Modulation of Activity of the Promoter of the Human <i>MDR</i> 1 Gene by Ras and p53Semantic proximity Read ↗

Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.Semantic proximity Read ↗

Multidrug resistance gene expression in acute myeloid leukemia: major prognosis significance for in vivo drug resistance to induction treatment.Semantic proximity Read ↗

Expression of the MDR1 gene in human cancers.Semantic proximity Read ↗

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.Semantic proximity Read ↗

Expression of some ATP-binding cassette transporters in acute myeloid leukemiaSemantic proximity Read ↗

Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid LeukemiasSemantic proximity Read ↗

[The significance of quantification of MDR1 and WT1 gene expression in acute myeloid leukemia].Semantic proximity Read ↗

[Clinical significance of multidrug resistance in acute leukemias].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.