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Article

Expression of genes related to multiple drug resistance and apoptosis in acute leukemia: response to induction chemotherapy.

Experimental and molecular pathology - 1 Feb 2012

Chauhan Pradeep Singh, Bhushan Bharat, Singh L C, Mishra Ashwani Kumar, Saluja Sumita, Mittal Vishakha, Gupta Dipendra Kumar, Kapur Sujala

Abstract excerpt

Resistance to chemotherapy is a major impediment to the successful treatment of acute leukemia (AL). Expression of genes involved in drug resistance and apoptosis may be responsible for this. This study aimed to investigate the expression of drug resistance (MDR1, MRP1, LRP, BCRP, GSTP1, DHFR) and apoptotic genes (p53, BCL-2, Survivin) in adult acute leukemias and compare them with clinical and hematological...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Identifiers

PMID: 22037714
DOI: 10.1016/j.yexmp.2011.09.004

Genes

DHFR
GSTP1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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