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Article

Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.

Leukemia & lymphoma - 1 Jul 2006

Ehmann Falk, Horn Stefan, Garcia-Palma Lizet, Wegner Wiebke, Fiedler Walter, Giehl Klaudia, Mayr Georg W, Jücker Manfred

Abstract excerpt

RAS genes, predominantly N-RAS and K-RAS, have been implicated in the pathogenesis of acute myeloid leukemia (AML), due to activating RAS mutations detectable in approximately 20% of AML patients. In the present study, RAS proteins were detected in their activated, GTP-bound form, in AML patients (n = 10) not expressing mutated forms of H-RAS, K-RAS and N-RAS. Further analysis revealed the simultaneous presence...

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PMID: 16923573
DOI: 10.1080/10428190600565925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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