Article
Multidrug resistance gene expression in acute myeloid leukemia: major prognosis significance for in vivo drug resistance to induction treatment.
Annals of hematology - 1 Feb 1997
Hunault M, Zhou D, Delmer A, Ramond S, Viguié F, Cadiou M, Perrot J Y, Levy V, Rio B, Cymbalista F, Zittoun R, Marie J P
Abstract excerpt
The clinical significance of the multidrug resistance (MDR 1) gene phenotype was investigated in newly diagnosed AML and was compared with other clinical and biological prognostic factors in patients who received at least one course of induction therapy with intercalating agents and conventional doses of Ara-C. MDR 1 gene was overexpressed in 40% of the 110 cases of AML at presentation, MRP in 15% of the 48...
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