Article
Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2005
Illmer Thomas, Thiede Christian, Fredersdorf Anke, Stadler Sylvia, Neubauer Andreas, Ehninger Gerhard, Schaich Markus
Abstract excerpt
PURPOSE: Activation of the RAS pathway plays a major role in cancer cells. In acute myeloid leukemia (AML), mutations of the RAS genes cause an intrinsic activation of this pathway. Until now, clinical studies could not find clear association of RAS mutations with the clinical outcome after AML therapy. This could be due to alternative initiating events for activation of the RAS pathway like constitutive tyrosine...
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