Article
MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct.
Journal of leukocyte biology - 1 Oct 2004
Getting Stephen J, Di Filippo Clara, Christian Helen C, Lam Connie W, Rossi Francesco, D'Amico Michele, Perretti Mauro
Abstract excerpt
Investigation of the mechanisms activated by endogenous inhibitory pathways can lead to identification of novel targets for cardiovascular inflammatory pathologies. Here we exploited the potential protective role that melanocortin receptor type 3 (MC3-R) activation might play in a myocardial ischemia-reperfusion injury model. In resting conditions, mouse and rat heart extracts expressed MC3-R mRNA and protein,...
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