Article
C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy.
Kidney international - 1 Jun 2017
Williams Allison Lesher, Gullipalli Damodar, Ueda Yoshiyasu, Sato Sayaka, Zhou Lin, Miwa Takashi, Tung Kenneth S, Song Wen-Chao
Abstract excerpt
C3 glomerulopathy is a potentially life-threatening disease of the kidney caused by dysregulated alternative pathway complement activation. The specific complement mediator(s) responsible for kidney injury in C3 glomerulopathy are yet to be defined and no specific therapy is currently available. We previously developed a mouse model of lethal C3 glomerulopathy with factor H and properdin gene double mutations....
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