Article
Phosphodiesterase genes and antidepressant treatment response: a review.
Annals of medicine - 1 Jan 2009
Esposito Karin, Reierson Gillian W, Luo Huai Rong, Wu Gui Sheng, Licinio Julio, Wong Ma-Li
Abstract excerpt
Depression results in a tremendous burden to individuals suffering from the disorder and to the global health economy. Available pharmacologic treatments for depression target monoamine levels and monoamine receptors. However, delayed onset of effect, partial or inadequate treatment response, and side-effects are significant limitations of current therapies. The search for a better understanding of mechanisms of...
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