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Article

Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3.

The Journal of biological chemistry - 6 Dec 2002

Rodionov Dmitrii G, Höning Stefan, Silye Aleksandra, Kongsvik Thomas L, von Figura Kurt, Bakke Oddmund

Abstract excerpt

Cytoplasmic tails of LIMPII and the invariant chain contain similar leucine-based sorting signals, but the invariant chain interacts only with AP1 and AP2, whereas LIMPII interacts strongly with AP3. In a series of in vitro experiments, we investigated the effect of residues upstream of the leucine pairs and demonstrated that these residues determine adapter binding, and certain residues favor interactions with...

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PMID: 12370188
DOI: 10.1074/jbc.M207149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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