Article
Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.
Molecular biology of the cell - 1 Feb 2007
Oestreich Andrea J, Aboian Mariam, Lee Jacqueline, Azmi Ishara, Payne Johanna, Issaka Rachel, Davies Brian A, Katzmann David J
Abstract excerpt
A subset of proteins that transit the endosomal system are directed into the intralumenal vesicles of multivesicular bodies (MVBs). MVB formation is critical for a variety of cellular functions including receptor down-regulation, viral budding, antigen presentation, and the generation of lysosome-related organelles. Entry of transmembrane proteins into the intralumenal vesicles of a MVB is a highly regulated...
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