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Article

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.

eLife - 25 Nov 2021

Pashkova Natalya, Gakhar Lokesh, Yu Liping, Schnicker Nicholas J, Minard Annabel Y, Winistorfer Stanley, Johnson Ivan E, Piper Robert C

Abstract excerpt

Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the internalization apparatus remains unclear. The internalization apparatus contains proteins such as Epsin and Eps15, which bind Ub, potentially acting as adaptors for Ub-based internalization signals. Here, we show that additional...

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Share to Clathrin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34821552
DOI: 10.7554/eLife.72583
PMCID: PMC8648300

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