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Article

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

Cell - 9 Mar 2007

Fisher Robert D, Chung Hyo-Young, Zhai Qianting, Robinson Howard, Sundquist Wesley I, Hill Christopher P

Abstract excerpt

ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX through YPX(n)L late-domain motifs (X = any residue; n = 1-3). Crystal structures reveal that human ALIX is composed of an N-terminal Bro1 domain and a central domain that is composed of two extended three-helix bundles that form...

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Identifiers

PMID: 17350572
DOI: 10.1016/j.cell.2007.01.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.PMID 17350572Read ↗

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