Article
Chromosome 6 suffers frequent and multiple aberrations in thymoma.
The American journal of pathology - 1 Oct 2002
Inoue Masayoshi, Marx Alexander, Zettl Andreas, Ströbel Philipp, Müller-Hermelink Hans-Konrad, Starostik Petr
Abstract excerpt
Thymoma is the most frequent tumor arising in human thymus. In this study, we performed a detailed mapping of deleted regions on chromosome 6 shown previously to harbor the most frequent genetic aberrations in this cancer. We analyzed 40 thymomas using 41 microsatellites. Two hundred ninety-four (23.5%) of 1253 informative genotypes showed loss of heterozygosity (LOH), only 39 (2.4%) were positive for...
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