Article
Thymic epithelial tumors can develop along two different pathogenetic pathways.
The American journal of pathology - 1 Nov 2001
Zhou R, Zettl A, Ströbel P, Wagner K, Müller-Hermelink H K, Zhang S, Marx A, Starostik P
Abstract excerpt
To investigate genetic abnormalities associated with the development of thymic epithelial tumors, we performed microsatellite analysis of 26 thymomas belonging to three different World Health Organization types (A, B3, and C) using 48 repeats. The most frequent aberration seen was loss of heterozygosity (LOH) in the region 6q23.3-25.3 detected in 11 tumors (45.8% of informative cases). Further consistent LOHs...
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