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Article

HCNP precursor protein transgenic mice display a depressive-like phenotype in old age.

Brain research - 19 Aug 2010

Matsukawa Noriyuki, Furuya Yoshiaki, Ogura Hiroo, Ojika Kosei

Abstract excerpt

We have previously reported a novel peptide, hippocampal cholinergic neurostimulating peptide (HCNP), which induces acetylcholine synthesis by increasing the amount of cholineacetyltransferase (ChAT) in medial septal nuclei. The HCNP precursor protein, composed of 186 amino acids, is an inhibitory factor of the c-Raf/ MEK cascade and may be involved in the development of the fetal rat brain via the inhibition of...

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Identifiers

PMID: 20599825
DOI: 10.1016/j.brainres.2010.06.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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