Article
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
European journal of gastroenterology & hepatology - 1 Oct 2002
Heinzlmann Maria, Lang Susanne M, Neynaber Sven, Reinshagen Max, Emmrich Joerg, Stratakis Diana F, Heldwein Walter, Wiebecke Baldur, Loeschke Klaus
Abstract excerpt
OBJECTIVES: Molecular screening for frequently mutated genes may increase the likelihood of identifying cancer risk groups, such as patients with longstanding inflammatory bowel disease. This study investigated the prevalence and time course of p53 and K-ras mutations in colonic lavage fluid of patients with inflammatory bowel disease. METHODS: Colonic lavage fluid from 190 patients with ulcerative colitis (73),...
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