Article
Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma.
Journal of clinical pathology - 1 Aug 1998
Mayall F, Jacobson G, Wilkins R, Chang B
Abstract excerpt
AIMS: To attempt to detect p53 gene mutations in the plasma of patients with large bowel carcinoma. METHODS: Plasma was collected from 20 control patients with no history of cancer and from 17 patients with large bowel carcinoma. Corresponding tumour and benign lymph node (control) samples for each of the carcinoma patients were obtained from paraffin blocks. A Dukes' stage was determined for each tumour. DNA was...
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