Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma.

doi:10.1136/jcp.51.8.611

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Article

Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma.

Journal of clinical pathology - 1 Aug 1998

Mayall F, Jacobson G, Wilkins R, Chang B

Abstract excerpt

AIMS: To attempt to detect p53 gene mutations in the plasma of patients with large bowel carcinoma. METHODS: Plasma was collected from 20 control patients with no history of cancer and from 17 patients with large bowel carcinoma. Corresponding tumour and benign lymph node (control) samples for ea...

Topics

Adult
Blood Specimen Collection
Colorectal Neoplasms
DNA, Neoplasm
Electrophoresis, Polyacrylamide Gel
Genes, p53
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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