Article
Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis.
The American journal of gastroenterology - 1 Feb 1999
Lashner B A, Shapiro B D, Husain A, Goldblum J R
Abstract excerpt
OBJECTIVE: Immunohistochemical staining for p53 suppressor gene mutations is sensitive and, therefore, has potential for use as a complementary test for dysplasia to improve ulcerative colitis (UC) cancer surveillance program performance. METHODS: A cohort of 95 patients with long standing pan-UC enrolled in a surveillance program was studied. Archival colonic biopsy specimens were stained for p53 mutations and...
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