Article
Comparison of flow cytometry and histology with mutational screening for p53 and Ki-ras mutations in surveillance of patients with long-standing ulcerative colitis.
Scandinavian journal of gastroenterology - 1 Dec 2001
Holzmann K, Weis-Klemm M, Klump B, Hsieh C J, Borchard F, Gregor M, Porschen R
Abstract excerpt
BACKGROUND: We evaluate the usefulness of screening for p53 and Ki-ras mutations in comparison with histological and flow cytometric findings. METHODS: We analyzed 1486 biopsy samples from 769 locations of 83 patients with long-standing ulcerative colitis enrolled in a surveillance program by means of histology, flow cytometry and SSCP analysis. As a control we used 66 biopsy samples of 16 patients with irritable...
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