CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes.

doi:10.1074/jbc.M205870200

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Article

CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes.

The Journal of biological chemistry - 6 Dec 2002

Cui Jie, Bian Jin-Song, Kagan Anna, McDonald Thomas V

Abstract excerpt

T-lymphocyte activation requires sustained Ca(2+) signaling dependent upon capacitative Ca(2+) entry (CCE). The protein(s) that forms the stores-operated Ca(2+) channel (SOCC) responsible for CCE has long been sought but has not been definitively identified. Members of the TRPV family (transient receptor potential superfamily-vanilloid receptor subfamily) of channel genes have been proposed to encode SOCCs...

Topics

Animals
CHO Cells
Calcium
Calcium Channels
Capsaicin
Cloning, Molecular
Cricetinae
DNA, Complementary
Genes, Dominant
Humans
Immunoblotting
Inositol 1,4,5-Trisphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Jurkat Cells

Microscopy, Fluorescence

Mutation

Reverse Transcriptase Polymerase Chain Reaction

TRPV Cation Channels

Time Factors

Source

Open in PubMed

Identifiers

PMID: 12361955
DOI: 10.1074/jbc.M205870200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12361955-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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