Article
CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes.
The Journal of biological chemistry - 6 Dec 2002
Cui Jie, Bian Jin-Song, Kagan Anna, McDonald Thomas V
Abstract excerpt
T-lymphocyte activation requires sustained Ca(2+) signaling dependent upon capacitative Ca(2+) entry (CCE). The protein(s) that forms the stores-operated Ca(2+) channel (SOCC) responsible for CCE has long been sought but has not been definitively identified. Members of the TRPV family (transient receptor potential superfamily-vanilloid receptor subfamily) of channel genes have been proposed to encode SOCCs...
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