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Article

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.

Nature cell biology - 1 Sept 2006

Huang Guo N, Zeng Weizhong, Kim Joo Young, Yuan Joseph P, Han Linhuang, Muallem Shmuel, Worley Paul F

Abstract excerpt

Receptor-evoked Ca2+ signalling involves Ca2+ release from the endoplasmic reticulum, followed by Ca2+ influx across the plasma membrane. Ca2+ influx is essential for many cellular functions, from secretion to transcription, and is mediated by Ca2+-release activated Ca2+ (I(crac)) channels and store-operated calcium entry (SOC) channels. Although the molecular identity and regulation of I(crac) and SOC channels...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16906149
DOI: 10.1038/ncb1454

Genes

STIM1
TRPC1
ORAI1
TRPC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.PMID 16906149Read ↗

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Semantic proximity Read ↗

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.Semantic proximity Read ↗

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel functionSemantic proximity Read ↗

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits.Semantic proximity Read ↗

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