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Article

TRPC1 participates in the HSV-1 infection process by facilitating viral entry.

Science advances - 1 Mar 2020

He DongXu, Mao AiQin, Li YouRan, Tam SiuCheung, Zheng YongTang, Yao XiaoQiang, Birnbaumer Lutz, Ambudkar Indu S, Ma Xin

Abstract excerpt

Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1-induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral...

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Source

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Identifiers

PMID: 32206724
DOI: 10.1126/sciadv.aaz3367
PMCID: PMC7080438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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