Article
Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+.
Neuroscience - 29 Dec 2010
Patil M J, Jeske N A, Akopian A N
Abstract excerpt
The transient receptor potential A1 (TRPA1) channel contributes to nociceptive signaling in certain pain models. It has been suggested that Ca(2+), which activates and modulates TRPA1, could play a critical regulatory role in this process. Since TRPA1 and transient receptor potential V1 (TRPV1) channels are co-expressed and interact in neurons, we investigated whether activation and modulation of TRPA1 by Ca(2+)...
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