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Article

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1.

The Journal of biological chemistry - 10 Apr 2009

Kim Min Seuk, Zeng Weizhong, Yuan Joseph P, Shin Dong Min, Worley Paul F, Muallem Shmuel

Abstract excerpt

With the discovery of STIM1 and Orai1 and gating of both TRPC and Orai1 channels by STIM1, a central question is the role of each of the channels in the native store-operated Ca(2+) influx (SOCs). Here, we used a strategy of knockdown of Orai1 and of TRPC1 alone and in combination and rescue by small interfering RNA-protected mutants (sm) of smOrai1 and smTRPC1 to demonstrate that in human embryonic kidney (HEK)...

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Source

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Identifiers

PMID: 19228695
DOI: 10.1074/jbc.M808097200
PMCID: PMC2665094

Genes

TRPC1
STIM1
TRPC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1.PMID 19228695Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

STIM1, an essential and conserved component of store-operated Ca2 <b>+</b> channel functionSemantic proximity Read ↗

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Semantic proximity Read ↗

The action of selective CRAC channel blockers is affected by the Orai pore geometry.Semantic proximity Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.Semantic proximity Read ↗

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