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Article

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.

Nature structural biology - 1 Oct 2001

Williams R S, Green R, Glover J N

Abstract excerpt

The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the...

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Share to BRCA1 Protein
Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Repetitive Sequences, Amino Acid

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Source

Identifiers

PMID: 11573086
DOI: 10.1038/nsb1001-838

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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